Vitamin C-Induced Oxalate Nephropathy in a Septic Patient

Vitamin C-Induced Oxalate Nephropathy in a Septic Patient

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OBJECTIVES:.Vitamin C is a novel treatment currently under investigation in the management of sepsis.Adverse renal effects of vitamin C through hyperoxaluria Toys have been described in the past.DATA SOURCES:.

We report the case of a 63-year-old man admitted in a community-based hospital with a diagnosis of sepsis of pulmonary origin.DATA EXTRACTION:.On day 19, despite a having developed oligoanuric acute kidney injury, a regimen of IV vitamin C, hydrocortisone, and thiamine was undertaken for 4 days.On day 23, the patient required renal replacement therapy with an estimated glomerular filtration rate of 7 mL/min.

Renal biopsy revealed extensive acute tubular necrosis associated with the presence of intratubular crystal of calcium oxalate.Conclusion:.Although vitamin C seems to be a possible therapeutic asset in the supportive care of sepsis patients, larger cohorts are fiesta® SKULL AND VINE required to ensure its safety and underlying or novel kidney injury should forewarn clinicians as to its use.